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Related article: CYP2J2: Arachidonic Acid, Inflammation, and Heart Disease Related article: Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation CYP1A1 is also utilized in the metabolism of melatonin .[ref] Related article: Melatonin: Key to Health and Longevity New research points to a role in immune homeostasis in the intestines .[ref] Toll-like receptor 2 (TLR2) is part of the immune system that is active in the intestines and interacts with the gut microbiome